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KMID : 1199120080320060488
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Korean Diabetes Journal
2008 Volume.32 No. 6 p.488 ~ p.497
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Cystatin C is a Valuable Marker for Predicting Future Cardiovascular Diseases in Type 2 Diabetic Patients
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Lee Seung-Hwan
Lee Kang-Woo
Kim Eun-Sook
Park Ye-Ree
Kim Hun-Sung
Park Shin-Ae
Kang Mi-Ja
Ahn Yu-Bae
Yoon Kun-Ho
Cha Bong-Youn
Son Ho-Young
Kwon Hyuk-Sang
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Abstract
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Background: Recent studies suggest that serum Cystatin C is both a sensitive marker for renal dysfunction and a predictive marker for cardiovascular diseases. We aimed to evaluate the association between Cystatin C and various biomarkers and to find out its utility in estimating risk for cardiovascular diseases in type 2 diabetic patients.
Methods: From June 2006 to March 2008, anthropometric measurements and biochemical studies including biomarkers for risk factors of cardiovascular diseases were done in 520 type 2 diabetic patients. A 10-year risk for coronary heart diseases and stroke was estimated using Framingham risk score and UKPDS risk engine.
Results: The Independent Variables Showing Statistically Significant Associations With Cystatin C Were Age (β = 0.009, P < 0.0001), Hemoglobin (β = -0.038, P = 0.0006), Serum Creatinine (β = 0.719, β < 0.0001), Uric Acid (β = 0.048, P = 0.0004), Log Hscrp (β = 0.035, P = 0.0021) And Homocysteine (β = 0.005, P = 0.0228). The Levels Of Microalbuminuria, Carotid Intima-media Thickness, Fibrinogen And Lipoprotein (A) Also Correlated With Cystatin C, Although The Significance Was Lost After Multivariate Adjustment. Calculated Risk For Coronary Heart Diseases Increased In Proportion To Cystatin C Quartiles: 3.3 ± 0.4, 6.2 ± 0.6, 7.6 ± 0.7, 8.4 ± 0.7% From Framingham Risk Score (P < 0.0001); 13.1 ± 0.9, 21.2 ± 1.6, 26.1 ± 1.7, 35.4 ± 2.0% From Ukpds Risk Engine (P < 0.0001) (Means ± Se).
Conclusions: Cystatin C is significantly correlated with various emerging biomarkers for cardiovascular diseases. It was also in accordance with the calculated risk for cardiovascular diseases. These findings verify Cystatin C as a valuable and useful marker for predicting future cardiovascular diseases in type 2 diabetic patients.
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KEYWORD
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Biomarkers, Cardiovascular disease, Cystatin C, Type 2 diabetes
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